Expression of ALCAM (CD166) and PD-L1 (CD274) independently predicts shorter survival in malignant pleural mesothelioma
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چکیده
منابع مشابه
CD274 (PD-L1)-Expression in colorectal cancer
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BACKGROUND Malignant pleural mesothelioma (MPM) is a rapidly fatal asbestos-associated malignancy with a median survival time of <1 year following diagnosis. Treatment strategy is determined in part using known prognostic factors. OBJECTIVE The aim of this study was to examine the relationship between asbestos exposure and survival outcome in MPM in an effort to advance the understanding of t...
متن کاملAnalysis of Expression of Programmed Cell Death 1 Ligand 1 (PD-L1) in Malignant Pleural Mesothelioma (MPM)
BACKGROUND The increasing incidence and poor outcome associated with MPM requires finding effective treatment for this disease. PD1/PD-L1 pathway plays a central role in tumor immune evasion and appears to be predictive and prognostic marker. PD-L1 is expressed in many different human cancers but its role in MPM has yet to be established. The aim of this study is to evaluate the expression of P...
متن کاملALCAM (CD166) Expression and Serum Levels in Pancreatic Cancer
BACKGROUND This study was conducted to evaluate the expression of the activated leukocyte cell adhesion molecule (ALCAM) in pancreatic cancer (PAC) and to determine whether or not the ectodomain shedding of ALCAM (s-ALCAM) could serve as a biomarker in the peripheral blood of PAC patients. MATERIAL AND METHODS Tissue specimens and blood sera of patients with PAC (n = 264 and n = 116, respecti...
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Malignant pleural mesothelioma is a lethal disease and little is known about prognostic factors. The prognostic significance of age, stage of disease, gender and histological subtype was studied in 167 new cases of cytologically (15%) or histologically (85%) proven malignant pleural mesothelioma in the Rotterdam area, during the period 1987-1989. Median survival of all patients was 242 days. Un...
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ژورنال
عنوان ژورنال: Human Pathology
سال: 2018
ISSN: 0046-8177
DOI: 10.1016/j.humpath.2017.04.032